Avena Sativa and Testosterone: The Common Oat & Hormones

By Ali Kuoppala | Last reviewed Mon 24 September 2018

Medical Review by Gerardo Sison, PharmD

Avena sativa or “the common oat” is the grain most people should be already quite familiar with.

There seems to be this general consensus among the bodybuilding world that oats and avena sativa supplements (which are basically glorified oat straw extracts) would be anabolic and pro-testosterone.

I have seen many claims about oat straw being used as a compound that would “regain hormonal balance” in men with low testosterone levels, without ever really seeing any proof of it.

In this article, we will take a closer look on the claims and research behind avena sativa, and whether it deserves to be called anabolic or not.

Oat Extract and Testosterone

oat straw extract and testosterone levelsAfter learning about the possible relationship with grains, gluten, prolactin and lowered testosterone levels1–3, I reduced my intake of gluten-rich grains.

However, oats aren’t that dense in gluten, and they were touted to contain steroidal saponins closely related to testosterone.

So I was – for quite some time – under the assumption that eating oats could be a good decision in terms of testosterone optimization.

Only recently, I started digging a little deeper on the topic of oats and testosterone, just to find that they might not be that great after all. Or at least, there would be absolutely no reason to actually supplement with avena sativa supplements.

Not so surprisingly, there wasn’t much of any research that would of have directly looked into the effects avena sativa has on testosterone production. Only thing I found were countless of articles rambling about similar jargon of “Avena sativa has been used for centuries, it’s been told to improve hormonal health and masculinity…” but with this kind of alt-med bullshit talk, you can only guess that there is never any actual cited research.

I had to dig a little deeper and start looking at the effects that isolated compounds within the oat straw have on hormones.

One of the principal compounds in avena sativa is a polysaccharride by the name of β-glucan, which has been found to suppress cholesterol production4. As to be expected, it’s hailed as some miracle compound, but like many of you already know, pointless reductions in cholesterol (unless its already abnormally high) often bring about reduced production of all steroid hormones (since cholesterol is the raw material for those5).

This seems to be the case with beta-glucan too. As a patented β-glucan supplement called Antrodan®, was tested in rodents and found to significantly suppress testicular size, reduce testosterone levels, and inhibit 5-alpha reductase enzyme and DHT6. In other words, β-glucan is an antiandrogen.

There are few other reasons why oats and avena sativa supplements might not be the best thing for testosterone, as oat straw is fairly high in pythic acid (which blocks absorption of several micronutrients7) and the fatty-acid content of oats is pretty high in testosterone suppressing omega-6 polyunsaturated fats.


Eating oats occasionally shouldn’t be enough to suppress your testosterone levels to any significant degree.

But I would argue that there’s absolutely no reason to claim that avena sativa supplements would be anabolic or increase testosterone. Quite the opposite, as their high content of β-glucan likely brings about antiandrogenic effects. At least it did so in rodents.

There are many proven supplements that are actually anabolic and well-proven to increase testosterone levels, so there’s really no need to look into avena sativa supplementation anyway. It’s simply an over-glorified oat extract with no benefits and a big price tag.


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Fanciulli G, Dettori A, Demontis M, Anania V, Delitala G. Serum prolactin levels after administration of the alimentary opioid peptide gluten exorphin B4 in male rats. Nutr Neurosci. 2004;7(1):53-55. [PubMed]
Delvecchio M, Faienza M, Lonero A, Rutigliano V, Francavilla R, Cavallo L. Prolactin may be increased in newly diagnosed celiac children and adolescents and decreases after 6 months of gluten-free diet. Horm Res Paediatr. 2014;81(5):309-313. [PubMed]
Othman R, Moghadasian M, Jones P. Cholesterol-lowering effects of oat β-glucan. Nutr Rev. 2011;69(6):299-309. [PubMed]
Schooling C, Au Y, Freeman G, Cowling B. The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials. BMC Med. 2013;11:57. [PubMed]
Peng C, Lin Y, Chen K, Chyau C, Peng R. Antrodan, a β-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia. Food Funct. 2015;6(2):635-645. [PubMed]
Schlemmer U, Frølich W, Prieto R, Grases F. Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009;53 Suppl 2:S330-75. [PubMed]

Ali Kuoppala

Ali Kuoppala is the founder of Anabolic Men. He has authored and co-authored multiple men's health books and focuses on uncovering the methods of optimizing hormonal health. To date, his articles on various websites have been read more than 15-million times. To read more about Ali, visit his Medium article.